Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association
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چکیده
منابع مشابه
Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association
Neural tube defects (NTDs) are the most common congenital defects of the central nervous system among neonates and the folate status during pregnancy was considered as the most important etiopathogenesis of NTDs. Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with i...
متن کاملMTR and MTRR polymorphisms, dietary intake, and breast cancer risk.
Methionine, the precursor for the universal methyl donor, S-adenosylmethionine, is produced through the irreversible transfer of a methyl group from 5-methyltetrahydrofolate. This reaction is regulated by two enzymes, methionine synthase (MTR) and methionine synthase reductase (MTRR). MTR is polymorphic at nucleotide 2,756 (A-to-G) and has been associated with decreased plasma homocysteine leve...
متن کاملAssociation of SMO polymorphisms and neural tube defects in the Chinese population from Shanxi Province.
OBJECTIVE This study aimed to investigate the single nucleotide polymorphisms (SNPs) of SMO and neural tube defects (NTDs) in Chinese population. METHOD A total of 113 NTDs cases and 138 healthy controls were used in this study. 10 selected single nucleotide polymorphism (SNP) sites in the SMO gene were analyzed with MassArray high-throughput DNA analyzer with matrix-assisted laser desorption...
متن کاملPolymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil.
Non-syndromic cleft lip and palate (CL/P) occurs due to interaction between genetic and environmental factors. Abnormalities in homocysteine metabolism may play a role in its etiology due to polymorphisms in genes involved in this pathway. Because of the involvement of MTHFR, MTR and MTRR genes with folate metabolism and the evidence that maternal use of folic acid in early pregnancy reduces th...
متن کاملrisk factors of neural tube defects in northern iran
background: neural tube defects (ntds) including spina bifida and anencephaly are the second most common birth defects with 2.8 per 1000 births in northern iran. objectives: this study was conducted to determine the risk factors of neural tube defects in gorgan, north of iran. patients and methods: this hospital-based, case-control study was carried out on all ntd-affected pregnancies (n = 59) ...
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ژورنال
عنوان ژورنال: Medicine
سال: 2015
ISSN: 0025-7974
DOI: 10.1097/md.0000000000001367